Cytodiagnostics provides custom conjugation of single stranded oligonucleotides or aptamers to gold nanoparticles with sizes ranging from 5nm-100nm in diameter. These conjugates can subsequently be incorporated into your downstream assays such as lateral flow
or vertical flow
, among others.
Through our collaborating partner InnovoGENE Biosciences
we also have the ability to assist you in the aptamer discovery process
for development of novel aptamers against your particular target of interest.
A successful standard conjugation reaction would result in a typical yield of 30ml* of your oligonucleotide-gold nanoparticle conjugate at an optical density of 1 (OD=1).
Our standard oligonucleotide gold nanoparticle conjugation service include:
- Synthesis of your single-stranded oligonucleotides for conjugation. Supply us with your sequence, and which terminal (5' or 3') to be attached to the gold surface, and we do the rest.
- Conjugation of your oligonucleotide to a gold nanoparticle size of your choice.
- Purification of conjugate.
*The yield stated above is just an average for a typical oligonucleotide, and not a guaranteed final volume of product. Oligonucleotide length and sequence might influence final yield.